ea0035p739 | Nuclear receptors and signal transduction | ECE2014
Brenmoehl Julia
, Albrecht Elke
, Komolka Katrin
, Schering Lisa
, Langhammer Martina
, Hoeflich Andreas
, Maak Steffen
The myokine irisin is secreted after cleavage of the transmembrane protein Fibronectin type III domain-containing protein five and was shown to induce a thermogenic program in white adipose tissue. This cleavage can be induced by exercise, thus linking exercise with browning of adipose tissue. We investigated the response of Fndc5/irisin as well as its inducer Peroxisome proliferator-activated receptor gamma co-activator 1α (Ppargc1a) in mice long-term selected for high t...